Improving robustness of industrial yeast strains using CRISPR/Cas9
Within this project, the student will alter the expression of different tolerance-related genes by CRISPRi. Eventually, beneficial alterations will be established permanently using CRISPR. Furthermore, strain tolerance will be will be evaluated through cultivations in small scale fermentations.
(Conditional) Generative Motion Modelling
Focus of this project is designing a generative temporal model that is able to synthesize novel human motion sequences.
Style Manifold of Digital Ink
By using generative temporal models we aim to learn interpretable representations of digital ink including handwritten text and hand-drawn sketches.
How can propionibacterium acnes cause back pain?
The aim of this project is to identify molecular mechanisms that may be explain pain development upon bacterial infection of the intervertebral disc, specifically by propionibacterium acnes.
Master’s project in protein engineering by directed evolution
In this project we will use directed evolution, an approach in protein engineering, to engineer biotin carboxylase for high activity with free biotin, as well as a small number of biotin analogs. This is a key step in engineering biotin-dependent carboxylases to act on novel substrates.
Master’s project in biochemical database design and implementation
In my group we use high-throughput methods to generate a large amount biochemical data for hundreds of enzymes. In this Master’s project we will design and implement a local SQLite database to store this data, make it available for easy retrieval, and make informative visualizations of that data.
Master’s project in data mining and protein sequence analysis
The evolutionary adaptations of living organisms are shaped by the environmental factors defining their habitat, but such data is often inaccessible. In this Master’s project we will mine microbial culturing protocols for growth condition data and use it for protein sequence analysis.
Synthesis and characterisation of electrospun carbon nanofibres as electrode framework for non-aqueous metal-air batteries
In this project novel carbon fibre based frameworks will be produced and assessed using a variety of analytical techniques. The focus of the project will be the interaction of the electrode with a number of room temperature ionic liquids that have been identified as possible electrolyte systems.
Investigation of a condensing gas boiler appliance
Numerical and experimental investigation of a condensing gas boiler appliance
Lagrangian Simulations of Fuel Injection
LES simulation of fuel injection and mixture formation processes relevant for internal combustion engines.
Automated identification of two-dimensional crystals based on optical contrast difference
The goal of this project is to develop an automated setup that is able to identify flakes of different thicknesses on Si/SiO2 substrates by analyzing the difference in optical contrast between the crystals and the substrate.
Analysis of Numerical Methods for Boundary Treatment in Wall-Bounded Turbulent Flow Simulations
In this project, a recently developed immersed boundary method for accurate Large-Eddy Simulations of compressible wall-bounded flows will be validated and applied to (simplified) internal combustion engine flows.
Electrospun, double-layered scaffolds for 3D Skin Tissue Engineered
This project is part of the Zurich Hochschulmedizin Flagship Project “Skintegrity”, with a collaboration between ETHZ and USZ. The student, who ideally has experience in electrospinning and cell culture, will participate in the development of double-layered nanonfibrous scaffolds for 3D skin tissue engineering.
Changes in the expression and activity of mechanosensors with age and degeneration
This project will investigate whether and how the expression and activity of TRP Channels changes with age and degeneration in the human intervertebral disc. Methods: qPCR, immunohistochemistry and immunoblotting to investigate expression and caclium Imaging or patchclamping to measure activity.
Development of a reflection-type near-field optical microscope
In this project a reflection-type near-field optical microscope will be designed, developed and characterized.
Project in mobile health systems
Develop and test personalized and efficient methods, devices and systems that can be used by anyone at the point-of-care to increase our ability to diagnose, monitor, prevent and treat major global health issues.
Biomimetic osteocyte culture in 3D printed structures
Osteocytes are widely accepted to be the main mechanosensor in bone. Using micro 3D printing, advanced surface coating technology and live cell microscopy, we are establishing a novel 3D cell model to study the mechanotransduction mechanisms at play.
Insilico Cell Mechanics: Finite Element Modelling of cell behaviour in mechanical characterisation
In our group we experimentally analyze the resistance of cells to substrate deformations. In the present project we plan to generate a finite element model of the cell response to biaxial stretching and use it to estimate cell stiffness from the experimental outcomes.
The role of early trauma on bone structure
In this project, the effects of early trauma on bone structure will be analyzed by microCT.

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