How can propionibacterium acnes cause back pain?
The aim of this project is to identify molecular mechanisms that may be explain pain development upon bacterial infection of the intervertebral disc, specifically by propionibacterium acnes.
Additive Manufacturing: Development of a flexible database solution for powder characterization and analysis
This work proposes the creation of a flexible database solution to save and safely store all the raw data from materials’ analyses, including and organizing the outputs of the tools used to charaterise powders for AM. Limited financial support might be available for not-ETH students (exchange).
Design of a Shear Flow Cell for Fluorescence Depolarization Studies in Liquids at Cryogenic Conditions
A research project is being conducted to study fluorescence depolarization as a means to detect fluid rotations down to the molecular scale. In the context of the project, a flow cell for liquid oxygen at 77K has to be designed and tested
Automated identification of two-dimensional crystals based on optical contrast difference
The goal of this project is to develop an automated setup that is able to identify flakes of different thicknesses on Si/SiO2 substrates by analyzing the difference in optical contrast between the crystals and the substrate.
Changes in the expression and activity of mechanosensors with age and degeneration
This project will investigate whether and how the expression and activity of TRP Channels changes with age and degeneration in the human intervertebral disc. Methods: qPCR, immunohistochemistry and immunoblotting to investigate expression and caclium Imaging or patchclamping to measure activity.
Development of a reflection-type near-field optical microscope
In this project a reflection-type near-field optical microscope will be designed, developed and characterized.
Image reconstruction for optical “PET”
FMT non-invasively resolves the three-dimensional distribution of fluorescent probes in vivo. Thus, it can be considered an optical version of PET (but only 1% cost of PET). The aim of the project is to improve the reconstruction algorithm for FMT.
Hardware development for optical “PET”
FMT non-invasively resolves the three-dimensional distribution of fluorescent probes in vivo. Thus, it can be considered an optical version of PET (but only 1% cost of PET). A miniaturized FMT with compact design and easy handling is certainly attractive. This calls for the integration of MEMS.
Investigation of cerebrovascular alterations in aging mouse models by multimodal imaging
Aging is a major risk factor for many neurodegenerative and metabolic diseases. Student will investigate the cerebrovascular, heamodynamic and pathphyiological alternations in brain of aging mouse model, by using high-resolution functional MRI, photoacoustic tomography and confocal microscopy.
Electrospun, double-layered scaffolds for 3D Skin Tissue Engineered
This project is part of the Zurich Hochschulmedizin Flagship Project “Skintegrity”, with a collaboration between ETHZ and USZ. The student, who ideally has experience in electrospinning and cell culture, will participate in the development of double-layered nanonfibrous scaffolds for 3D skin tissue engineering.
The role of early trauma on bone microarchitecture and innervation
In this project, the direct and epigenetic effects of early trauma on bone microarchitecture and innervation will be analyzed by microCT, qPCR and immunostaining.
Improving robustness of industrial yeast strains using CRISPR/Cas9
Within this project, the student will alter the expression of different tolerance-related genes by CRISPRi. Eventually, beneficial alterations will be established permanently using CRISPR. Furthermore, strain tolerance will be will be evaluated through cultivations in small scale fermentations.

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