Electrospun, double-layered scaffolds for 3D Skin Tissue Engineered
This project is part of the Zurich Hochschulmedizin Flagship Project “Skintegrity”, with a collaboration between ETHZ and USZ. The student, who ideally has experience in electrospinning and cell culture, will participate in the development of double-layered nanonfibrous scaffolds for 3D skin tissue engineering.
The role of early trauma on bone microarchitecture and innervation
In this project, the direct and epigenetic effects of early trauma on bone microarchitecture and innervation will be analyzed by microCT, qPCR and immunostaining.
Hardware development for optical “PET”
FMT non-invasively resolves the three-dimensional distribution of fluorescent probes in vivo. Thus, it can be considered an optical version of PET (but only 1% cost of PET). A miniaturized FMT with compact design and easy handling is certainly attractive. This calls for the integration of MEMS.
Improving robustness of industrial yeast strains using CRISPR/Cas9
Within this project, the student will alter the expression of different tolerance-related genes by CRISPRi. Eventually, beneficial alterations will be established permanently using CRISPR. Furthermore, strain tolerance will be will be evaluated through cultivations in small scale fermentations.
Multimodal analysis framework for optoacoustic tomography and magnetic resonance imaging
We seek to develop an multimodal analysis framework for imaging data from optoacoustic tomography and magnetic resonance imaging, which enables accurate quantification and insights into rodent physiology.
How can propionibacterium acnes cause back pain?
The aim of this project is to identify molecular mechanisms that may be explain pain development upon bacterial infection of the intervertebral disc, specifically by propionibacterium acnes.
Additive Manufacturing: Development of a flexible database solution for powder characterization and analysis
This work proposes the creation of a flexible database solution to save and safely store all the raw data from materials’ analyses, including and organizing the outputs of the tools used to charaterise powders for AM. Limited financial support might be available for not-ETH students (exchange).
Automated identification of two-dimensional crystals based on optical contrast difference
The goal of this project is to develop an automated setup that is able to identify flakes of different thicknesses on Si/SiO2 substrates by analyzing the difference in optical contrast between the crystals and the substrate.
Changes in the expression and activity of mechanosensors with age and degeneration
This project will investigate whether and how the expression and activity of TRP Channels changes with age and degeneration in the human intervertebral disc. Methods: qPCR, immunohistochemistry and immunoblotting to investigate expression and caclium Imaging or patchclamping to measure activity.
Development of a reflection-type near-field optical microscope
In this project a reflection-type near-field optical microscope will be designed, developed and characterized.

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