Parameter Optimisation of a Degradable Microfiber Patch

Degradable microfiber patches are a promising scaffold for tendon and ligament repair, offering tunable mechanics and topographical cues that guide tenocyte alignment. However, the effects of key design parameters (fiber material, diameter, layer architecture, and patch density) remain poorly characterised, limiting development to trial-and-error. This thesis systematically varies these parameters and evaluates their mechanical, biological, and structural outcomes to establish rational design rules for clinical application. The six-month project is suited to candidates with backgrounds in biomedical engineering or materials science and skills in biomaterials processing, mechanical testing, cell culture, and data analysis.

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